ANTIBACTERIAL AND PLASMID ELIMINATION AGENTS

摘要

Inhibitors of the tmRNA pathway have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest. Identified cyclic or linear peptides are further selected by in vivo selection methods, kill bacterial pathogens when added exogenously, and/or eliminate plasmids carrying antibiotic resistance or virulence genes. The molecular target of each cyclic peptide is in the tmRNA pathway and the tmRNA pathway is inhibited in vitro and in vivo by the addition of the peptides.

主权项

1. A nucleic acid comprising a promoter operably linked to a nucleotide sequence encoding a luciferase, wherein the nucleotide sequence is operably linked at its 3′ end to at least one tmRNA targeting sequence.