OXANORBORNADIENE DERIVATIVES AND THEIR ANTICANCER ACTIVITIES

摘要

The present invention relates to chemical entities originated from natural sources and further synthesized for therapeutic uses. More particularly, the present invention relates to norcantharidin analogues synthesized by a transition metal-catalyzed alkynylation of oxanorbornadiene derivatives and their antitumor effects.

主权项

1. A composition comprising norcantharidin analogues represented by a general formula of (I): wherein R1 and R2 are independently or jointly selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, amine, nitro, alkylthio, or heteroalkyl; and wherein R3, R4, R5, R6, and R7 are independently or jointly selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxyl, alkoxyl, amine, nitro, nitrile, alkylthio, trifluoromethyl, alkyl sulfonyl, or aryl sulfonyl.