Oxide Ferrimagnetics with Spinel Structure Nanoparticles and Iron Oxide Nanoparticles, Biocompatible Aqueous Colloidal Systems Comprising Nanoparticles, Ferriliposomes, and Uses Thereof

摘要

The present invention relates to methods for producing oxide ferrimagnetics with spinel structure and iron oxide nanoparticles by soft mechanochemical synthesis using inorganic salt hydrates, oxide ferrimagnetics with spinel structure and iron oxide nanoparticles of ultra-small size and high specific surface area obtainable by the methods, biocompatible aqueous colloidal systems comprising oxide ferrimagnetics with spinel structure and iron oxide nanoparticles, carriers comprising oxide ferrimagnetics with spinel structure and iron oxide nanoparticles, and uses thereof in medicine.

主权项

1. A suspension comprising:
iron oxide nanoparticles or oxide ferrimagnetics with spinel structure nanoparticleshaving a size between about 3 nm and 14 nm, wherein the size of 70% of the nanoparticles is smaller than 8 nm, wherein the nanoparticles are obtained by soft mechanochemical synthesis using a crystal hydrate salt of Fe; and
a biocompatible saline solution being a sterile multiplex buffer comprising:
(i) from about 50 to about 500 mM of NaCl;(ii) from about 200 to about 2 mM of citrate buffer; and(iii) about 100 to about 1 mM of HEPES;wherein the buffer has a pH from about 4.0 to about 10.0.