发明名称 |
SUSTAINED-RELEASE LIPID PRE-CONCENTRATE OF CATIONIC PHARMACOLOGICALLY ACTIVE SUBSTANCE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
摘要 |
Disclosed is a sustained-release lipid pre-concentrate, comprising: a) at least one liquid crystal former; b) at least one neutral phospholipid; c) at least one liquid crystal hardener; and d) at least one anionic anchoring agent, wherein the sustained-release pre-concentrate exists as a lipid liquid phase in the absence of aqueous fluid and forms into a liquid crystal upon exposure to aqueous fluid. The sustained-release lipid pre-concentrate is configured to enhance the sustained release of cationic pharmacologically active substance through ionic interaction between the anionic anchoring agent and the cationic pharmacologically active substance. |
申请公布号 |
WO2014104784(A1) |
申请公布日期 |
2014.07.03 |
申请号 |
WO2013KR12259 |
申请日期 |
2013.12.27 |
申请人 |
CHONG KUN DANG PHARMACEUTICAL CORP. |
发明人 |
YU, HA NA;BAIK, HYE JUNG;YANG, WON KYU;KO, JIN YOUNG;JUNG, SUNG BUM;AN, SUNG WON;KI, MIN HYO |
分类号 |
A61K9/20;A61K9/06;A61K9/08;A61K47/30 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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