发明名称 |
METHODS OF PRODUCING 7-CARBON CHEMICALS FROM LONG CHAIN FATTY ACIDS VIA OXIDATIVE CLEAVAGE |
摘要 |
<p>This document describes biochemical pathways for producing pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol by forming two terminal functional groups, comprised of carboxyl, amine or hydroxyl group, in a C7 aliphatic backbone substrate. These pathways, metabolic engineering and cultivation strategies described herein rely on the fatty acid synthesis pathway and oxidative cleavage of long chain acyl-[acp] intermediates by a monooxgenase (e.g., cytochrome P450) such as that encoded by BioI from microorganisms such as Bacillus subtillis.</p> |
申请公布号 |
WO2014105793(A1) |
申请公布日期 |
2014.07.03 |
申请号 |
WO2013US77419 |
申请日期 |
2013.12.23 |
申请人 |
INVISTA NORTH AMERICA S.A.R.L. |
发明人 |
BOTES, ADRIANA LEONORA;CONRADIE, ALEX VAN ECK;CHEN, CHANGLIN;PEARLMAN, PAUL S. |
分类号 |
C12P7/18;C12P7/42;C12P7/44;C12P13/00 |
主分类号 |
C12P7/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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