NOVEL AMPK AGONIST COMPOSITIONS AND METHODS OF USE

摘要

The invention relates to novel AMPK agonist containing compositions that are adapted for localised use in treating inflammation and/or pain due to disease or injury in a human or animal. The novel compositions of the invention are useful in the treatment of a variety of conditions including osteoarthritis (OA), synovitis, tendonitis, desmitis; cystitis, osteitis and laminitis. Routes of administration include intra-articular, direct injection into tissues, instillation, retrograde perfusion and topical. AMPK agonists which can be used include AICAR, metformin, phenformin, A-769662, resveratrol, berberine and polyphenols.

主权项

1. A composition adapted for the localized treatment and/or prevention of a disease condition or traumatic injury in a subject comprised of a therapeutically effective amount of a suitable agonist of AMP-activated protein kinase (AMPK).