INHIBITION OF INFLAMMATION USING ANTAGONISTS OF MUC1

摘要

The invention provides for peptides from the MUC1 cytoplasmic domain and methods of use therefor. These peptides can inhibit MUC1 oligomerization, inhibit the interaction of MUC1 with NF-κB or a STAT, and block inflammatory response mediated by NF-κB or STAT signaling.

主权项

1. A method of inhibiting inflammatory signaling in a subject suffering from acute pancreatitis comprising contacting said cell with a MUC1 peptide of at least 6 consecutive MUC1 residues and no more than 20 consecutive MUC1 residues and comprising the sequence CQCRRK.