发明名称 |
DELIVERY OF BIOLOGIC THERAPEUTICS |
摘要 |
Formulations and methods are disclosed which provide controlled, sustained release of a biologic therapeutic to a space within the body. More specifically, formulations comprising a plurality of hydrophilic polymer strands, and methods of forming and administering such formulations, are disclosed. In some embodiments, the formulations exhibit a burst release, an initial release, a triphasic release, and release over thirty to ninety days of the biologic therapeutic. In some embodiments, the formulations exhibit reversible precipitation of the biologic therapeutic into precipitates having a diameter of about 50 nm to about 10 μι&eegr;. |
申请公布号 |
WO2014106116(A2) |
申请公布日期 |
2014.07.03 |
申请号 |
WO2013US78102 |
申请日期 |
2013.12.27 |
申请人 |
ABBOTT CARDIOVASCULAR SYSTEMS INC. |
发明人 |
TROLLSAS, MIKAEL;STANKUS, JOHN;SU, JAMES;HOSSAINY, SYED;SMITH, JOSHUA, TAKESHI;ASKA, SHADID |
分类号 |
A61K9/00;A61K9/08;A61K9/14;A61K38/00;A61K38/19;A61K38/21;A61K39/00;A61K47/10;A61K47/48;C07K16/18 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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