METHOD OF ADMINISTERING AN ANTIBODY

摘要

Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for α4β7 integrin. Preferably, no more than about 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month.

主权项

1. A method for inhibiting relapse and/or recurrence of quiescent inflammatory bowel disease in a human, comprising administering to said human an effective amount of a humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for human α4β7 integrin, said humanized immunoglobulin or antigen-binding fragment comprising an antigen binding region of nonhuman origin and at least a portion of an immunoglobulin of human origin, wherein said humanized immunoglobulin or antigen-binding fragment is administered in doses and the minimum interval between doses is a period of about one month, and wherein no more than about 8 mg humanized immunoglobulin or antigen-binding fragment per kg body weight are administered during a period of about one month; wherein said humanized immunoglobulin or antigen-binding fragment has binding specificity for the α4β7 complex, wherein said antigen-binding region comprises three complementarity determining regions (CDR1, CDR2 and CDR3) of a light chain variable region and three complementarity determining regions (CDR1, CDR2 and CDR3) of a heavy chain variable region of the amino acid sequence set forth below:light chain:CDR1SEQ ID NO: 9CDR2SEQ ID NO: 10CDR3SEQ ID NO: 11heavy chain:CDR1SEQ ID NO: 12CDR2SEQ ID NO: 13CDR3SEQ ID NO: 14.