T-Cell Vaccination With Viral Vectors Via Mechanical Epidermal Disruption

摘要

Attenuated, replication-deficient viruses such as vaccinia viruses are used to deliver an exogenous viral, bacterial, parastic or tumor antigen to an epidermal tissue such as the skin, lungs or gastrointestinal tract, which has been mechanically disrupted, in an amount effective to elicit or stimulate a cell mediated immune response. The epidermis may be mechanically disrupted prior to, at the same time, or immediately after the administration of the vaccine. The vaccine can be used to induce immunity against a pathogen, such as a virus, bacteria, or parasite, or against a cancer in a subject that has or is at risk of developing cancer.

主权项

1. A method for inducing or stimulating a protective T cell mediated immune response to an exogenous T cell antigen in epithelial tissues selected from the group consisting of skin, lung, oral mucosa, gastrointestinal tract, and reproductive mucosa comprising administering to mechanically disrupted epithelial tissue a live, modified, non-replicating or replication-impaired virus expressing the antigen in an amount sufficient to stimulate the immune response.