HSP70 BINDING COMPOUND, USE, ANTITUMOUR PHARMACEUTICAL COMPOSITION, GENE CONSTRUCT FOR EXPRESSING AN HSP70 BINDER, PRODUCTION PROCESS, PROCESS FOR EVALUATING TUMOUR CELLS, METHOD OF SENSITIZATION OF TUMOUR CELLS TO CHEMOTHERAPEUTIC DRUGS

摘要

The present invention provides the use of the HspBP1 protein or portion thereof in preparing an antitumour pharmaceutical composition, the combination thereof with one or more chemotherapeutic agents being optional. The following are also disclosed: a gene construct for expressing said binder, a production process, a process for evaluating tumour cells, and a method of sensitization of tumours to chemotherapeutic drugs. The invention also provides a novel in vivo and in vitro experimental model for developing/evaluating antitumour agents. The pharmaceutical compositions of the invention provide antitumour activity and are highly specific for neoplastic cells, resulting in less cytotoxicity for cells with normal cell division. These and other advantages of the invention characterize a solution for the inconveniences of the currently known chemotherapeutic treatments.