发明名称 NOVEL BENZAZEPINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
摘要 The objective of the present invention is to provide a compound which has V2 receptor agonistic activity. A pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. (In general formula (I), R1 represents a group represented by formula (2) or the like; R2 represents a hydrogen atom or a lower alkyl group; R3 represents a lower alkyl group which may be substituted by 1-3 fluorine atoms, or a halogen atom; R4 represents a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group or the like (provided that these heterocyclic groups have at least one nitrogen atom and may be substituted by a lower alkyl group); and R5 represents a lower alkyl group, a halogen atom or the like.) (In formula (2), A represents a lower alkylene group which may be substituted by a lower alkyl group, or the like; R6 represents a hydrogen atom or the like; and R7 represents a hydroxyl group, an aromatic heterocyclic group which may be substituted by a lower alkyl group, a carbamoyl group or the like.)
申请公布号 WO2014104209(A1) 申请公布日期 2014.07.03
申请号 WO2013JP84937 申请日期 2013.12.26
申请人 SANWA KAGAKU KENKYUSHO CO., LTD. 发明人 KITAMOTO KATSUNORI;KASUGAI NOBUYOSHI;KATAOKA HIROYO;OHSAWA YASUSHI;KUNO YUKA;FUJIEDA HIROKI;SAKAI KEITA;NAGANO HIROKI;TAKAHASHI NAOKI;IZUCHI TORU;TAKEUCHI MITSUAKI;KURUMAZUKA DAISUKE;MIYAZAWA TOSHIYUKI;HARADA SATOKO;GOTOH IZUMI;ASANO YUKIYASU;YAMADA YURIE;OKABE MORIO
分类号 C07D223/16;A61K31/55;A61P7/04;A61P13/00;A61P13/10;A61P43/00;C07D403/10;C07D413/10 主分类号 C07D223/16
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