PHARMACEUTICAL COMPOSITION WITH IMPROVED STABILITY, CONTAINING TEMOZOLOMIDE, AND PREPARATION METHOD THEREFOR

摘要

The present invention relates to: a dry granule containing temozolomide, and tartaric acid as a pH stabilizer; a pharmaceutical composition with improved stability containing the same; and a preparation method therefor. A preparation according to the present invention is improved in pH and moisture stability while maintaining a conventional dissolution pattern, thereby securing the stability of temozolomide, which is a main drug, after the processing and packaging steps, and the preparation can be stored for a long time. In addition, productivity is improved by enhancing flowability, and the preparation can be useful for treating a brain tumor by being applied to an oral formulation and maintaining remarkable content uniformity and drug activities.