A COMPOUND 1,4,5-TRISUBSTITUTED1,2,3-TRIAZOLE, PROCESS TO OBTAIN IT AND USES THEREOF

摘要

The present invention relates to nonpeptide compounds of formula (I), containing a central 1,4,5- trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent "click" bonds on the surface of materials functionalized with reactive groups including: azide, terminal alkyne, cyclooctalkyne, thiol, maleimide or thiolacid groups. These compounds are nonpeptide mimetics of RGD (Arg-Gly- Asp) and/or OGP10-14 (Tyr-Gly-Phe-Gly-Gly), osteogenic peptides. Also, the present invention relates to a process for the preparation of the compounds containing a 1,4,5-trisubstituted 1,2,3-triazole core. These compounds are particularly useful for medical devices, in particular implants and tissue engineering and cell culture matrices.