发明名称 ROTAVIRUS PREPARATIONS WITH EXCESS CALCIUM IONS AND HIGH VISCOSITIES THAT ENSURE VACCINE VIABILITY AT ELEVATED TEMPERATURES
摘要 <p>The invention describes a set of formulations and methods that provide for stabilization of viruses in liquid and dried states. In particular, formulations include Rotavirus preparations with excess Ca2+ and high viscosities that ensure infective potency at elevated temperatures. Methods include bulk purification of Rotavirus from cell culture and administration of formulations as vaccines including components for gastric neutralization.</p>
申请公布号 EP2747777(A2) 申请公布日期 2014.07.02
申请号 EP20120825167 申请日期 2012.08.25
申请人 PULLIAM, BRIAN 发明人 PULLIAM, BRIAN
分类号 A61K39/12;A61K39/00;A61K39/15;A61K47/02;C12N7/00 主分类号 A61K39/12
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