发明名称 |
ENHANCED ANTISENSE OLIGONUCLEOTIDES |
摘要 |
<p>Described herein are gap-widened antisense oligonucleotides having improved therapeutic index as compared to 5-10-5 MOE gapmer antisense oligonucleotides of the same sequence. Also described are methods of reducing a target RNA in an animal using the gap-widened antisense oligonucleotides of the present invention. Further, are methods for selecting a gap-widened antisense oligonucleotides.</p> |
申请公布号 |
EP1799859(B1) |
申请公布日期 |
2014.07.02 |
申请号 |
EP20050798891 |
申请日期 |
2005.09.19 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
MONIA, BRETT, P.;SIWKOWSKI, ANDREW, M.;BHANOT, SANJAY |
分类号 |
C12Q1/68;A01N43/04;C07H21/02;C07H21/04;C12N15/11;C12N15/63;C12N15/88;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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