| 摘要 |
The present invention relates to a composition for preventing, alleviating, or treating bone diseases, wherein the composition uses a desmodii herba extract as an active ingredient so as to control the differentiation of osteoclasts and the expression of c-Fos and NFATc1 so that bone diseases including osteoporosis can be prevented, alleviated, or treated. The composition according to the present invention is extracted from a natural material so that side effects do not occur and the differentiation of osteoclasts is controlled. Moreover, the expression of c-Fos and NFATc1 which is a major mechanism of the differentiation of osteoclasts is strongly controlled. Furthermore, the expression of osteoclast induction factors including TRAP, OSCAR, cathepsin K, and DC-STAMP which are activated by means of M-CSF and RANKL is controlled, and the activation of MAPK paths including ERK, JNK, p38, etc. is controlled. |
