发明名称 |
METHOD OF TREATING MULTIPLE SCLEROSIS BY INTRATHECAL DEPLETION OF B CELLS AND BIOMARKERS TO SELECT PATIENTS WITH PROGRESSIVE MULTIPLE SCLEROSIS |
摘要 |
<p>Described herein are methods of treating multiple sclerosis (MS), such as secondary progressive MS (SPMS), by intrathecally administering a B cell depleting agent, such as rituximab, alone or in combination with intravenous administration of a B cell depleting agent. Also described is the use of IL-12p40, CXCL13, or both as CSF biomarkers for selecting a patient with progressive MS as a candidate for treatment with an intrathecal immunomodulatory therapy, and for identifying a progressive MS patient as having meningeal inflammation. The present disclosure also describes a method of evaluating the effectiveness of a therapy for treating progressive MS by measuring the level of IL-12p40, CXCL13, or both in the CSF of the patient before and after treatment. A decrease in the level of IL-12p40, CXCL13, or both after treatment indicates the therapy is effective for treating progressive MS.</p> |
申请公布号 |
EP2748198(A2) |
申请公布日期 |
2014.07.02 |
申请号 |
EP20120769299 |
申请日期 |
2012.09.27 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BIELEKOVA, BIBIANA;HERMAN, MATTHEW, L. |
分类号 |
C07K16/28;A61P25/00;A61P37/06;G01N33/53 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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