The present invention relates to oligonucleotide-encoded libraries and methods of tagging such libraries. In particular, the methods and oligonucleotides can include one or more 2′-substituted nucleotides, such as 2′-O-methyl or 2′-fluoro nucleotides, and other conditions or reagents to enhance enzyme ligation or one or more chemical functionalities to support chemical ligation.
申请公布号
EP2748357(A1)
申请公布日期
2014.07.02
申请号
EP20120830083
申请日期
2012.09.07
申请人
X-CHEM, INC.
发明人
KEEFE, ANTHONY, D.;WAGNER, RICHARD, W.;LITOVCHICK, ALEXANDER;CLARK, MATTHEW;CUOZZO, JOHN, W.;CENTRELLA, PAOLO A.;ZHANG, YING;HUPP, CHRISTOPHER D.