Methods and apparatus for pasadena hyperpolarization

摘要

The present subject matter relates to methods and apparatus for using hyperpolarization to improve imaging. Am exemplary embodiment, a PASADENA polarizer, is capable of delivering 2.5-5 ml of highly hyperpolarized biological 13C and 15N imaging reagents in less than one minute, and capable of repeated delivery every 5-8 minutes. Exemplary quality control sequences are also provided to create versatile methods, systems, and apparatuses for a variety of biomolecules, capable of undergoing reaction with parahydrogen necessary for effective PASADENA. The subject matter simplifies the technology for routine liquid state generation of hyperpolarized molecules for 13C and 15N subsecond imaging and spectroscopy in vivo and further advance the clinical application of this technology. Methods and systems for providing magnetic shielding are also provided.

主权项

1. An apparatus for hyperpolarization, comprising:
a reaction chamber for hyperpolarization; a transmitter device for transmission of radio frequency (R.F.) pulses into the reaction chamber; a static magnetic field generator for generating a static magnetic field surrounding the reaction chamber; and a plurality of valves employed for fluid and/or gas flow and delivery to and from the reaction chamber; wherein an image reagent solution is introduced, via one of the valves in the plurality, into and hyperpolarized within the reaction chamber.