| 主权项 |
1. A compound having a structural formula: wherein Ra is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ORe, N(Re)2, and SRe; alternatively, either Ra and R1 or NRe and R1 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic or heterocyclic ring; Rb is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ORe, N(Re)2, and SRe, alternatively, either Rb and R6 or NRe and R6 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic ring or a five or six-membered aliphatic carbocyclic or heterocyclic ring; Rc is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6hydroxyalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(═O)Re, or Rc and Rd are taken together to form a five, six, or seven-membered aliphatic ring, optionally containing an oxygen atom; Rd is selected from the group consisting of hydrogen, C1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(═O)Re, or Rd and R7 together with the atoms to which they are attached form a five or six-membered aliphatic ring; Re, independently, is selected from the group consisting of hydrogen, C1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, or two Re groups taken together with a nitrogen to which they are attached to form a five or six-membered aliphatic ring; R1, R2, R3, R4, R5, and R6, independently, are selected from the group consisting of hydrogen, C1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, ORe, C(═O)Re, C(═O)ORe, OC(═O)Re, C(═O)N(Re)2, C(═O)NReSO2Re, N(Re)2, NReC(═O)Re, NReC(═O)N(Re)2, CN, NO2, CF3, OCF3, SRe, SORe, SO2Re, SO2N(Re)2, and OSO2CF3; R7 is selected from the group consisting of hydrogen, C1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and n is 1, 2, 3, 4, or 5, or a pharmaceutically acceptable salt or hydrate thereof. |
