LSA-5 liver stage and blood stage antigen of <i>Plasmodium falciparum</i>, immunogenic composition comprising said antigen, and vaccines against malaria

摘要

The present invention pertains to the protection against malaria. More particularly, the invention is based on the characterization of a novel liver and sporozoite-stage P. falciparum antigen, referred to as LSA-5. This antigen is highly antigenic and the prevalence of antibodies in subjects living in endemic areas is extremely high (ca. 90%). The invention concerns antigenic peptides, mixtures thereof, or polypeptides, mixotopes and conjugates comprising part of the sequence of LSA-5, as well as immunogenic compositions, vaccines and kits comprising these.

主权项

1. An isolated antigenic polypeptide, comprising at least a consensus LSA-5 peptide of sequence EEVVEELIEEVIPEELVL (SEQ ID NO: 15).