发明名称 |
Compounds useful as inhibitors of ATR kinase |
摘要 |
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.;The compounds of this invention have formula I:;
wherein the variables are as defined herein.
;Additionally, the present invention also relates to novel processes for the production of various morpoholine based intermediates. |
申请公布号 |
US8765751(B2) |
申请公布日期 |
2014.07.01 |
申请号 |
US201213631730 |
申请日期 |
2012.09.28 |
申请人 |
Vertex Pharmaceuticals Incorporated |
发明人 |
Charrier Jean-Damien;Young Stephen Clinton;Davis Christopher John;Studley John |
分类号 |
A61K31/535;A61K31/5377;C07D413/14;C07D413/04;C07D413/10 |
主分类号 |
A61K31/535 |
代理机构 |
|
代理人 |
Che Jennifer G. |
主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt thereof. |
地址 |
Boston MA US |