Apparatus and method for pre-conditioning/fixation and treatment of disease with heat activation/release with thermoactivated drugs and gene products

摘要

An apparatus and method for administering focused energy to a body using either a single energy applicator or multiple energy applicators to supply heat prior to, concurrently with and/or after delivery of a drug, gene and/or viral vector. A multi-modality treatment using a localized, focused and/or regional heating apparatus, which supplies heat to a defined area of a patient's body. The apparatus is used heat is used to pretreat a specific body site, to activate thermoactivated drugs, genes, or viral vectors, and/or to deliver drugs, genes, or viral vectors to the specific body site. The heating apparatus is provided with one or more variable and adjustable probes and one or more delivery ports heat the specific treatment site and to deliver the thermoactivated drugs and genes to the specific treatment site. Each probe may optionally be provided with one or more temperature sensors to allow for the temperature in the specific treatment site and the surrounding tissue to be properly regulated. The use of the apparatus and method allow for the heat conditioning of a specific treatment site and for the delivery or activation of a drug, gene, or viral vector limited to only the specific treatment site, allowing for a more accurate treatment of diseased tissue without damaging healthy tissue. In addition, this method is uniquely used with non invasive technologies to help determine on a real time basis the completion of the treatment.

主权项

1. An apparatus for administering a focused treatment into a targeted tissue region of a patient's body comprising:
a catheter comprising a distal tip adapted to penetrate the targeted tissue region within the body and at least one catheter port located at the distal tip; a plurality of adjustable probes moveably disposed within the catheter, each of the plurality of adjustable probes comprising a distal tip adapted to penetrate tissue, at least one of said adjustable probes being an energy delivering probe comprising one or more energy delivery ports; a plurality of heating prongs configured to extend out of the energy delivery ports of said at least one adjustable probe for treating differently shaped treatment zones; and a controller adapted for independently extending each of said plurality of adjustable probes out of the catheter port and into the targeted tissue region after the distal tip is inserted into the targeted tissue.