| 发明名称 | Method of manufacturing tablet | ||
| 摘要 | A method of manufacturing a tablet containing coated granules comprising compressing the coated granules containing biologically active substance and having a temperature exceeding a room temperature, whereby the tablet can be prevented from rupture of a part of a coating film of the granules at the time of tablet compression. | ||
| 申请公布号 | US8765176(B2) | 申请公布日期 | 2014.07.01 |
| 申请号 | US200210477478 | 申请日期 | 2002.06.19 |
| 申请人 | Takeda Pharmaceutical Campany Limited | 发明人 | Yamamoto Keiichi;Mizukami Yoshio;Izutsu Daisuke |
| 分类号 | A61K9/20;A61K9/28;B29C41/32;B29C41/46;B30B15/34;A61J3/10;A61J3/00;A61K9/24;A61K9/00;B30B11/08;A61K9/50 | 主分类号 | A61K9/20 |
| 代理机构 | Hamre, Schumann, Mueller & Larson, P.C. | 代理人 | Hamre, Schumann, Mueller & Larson, P.C. |
| 主权项 | 1. A method of manufacturing a tablet, which comprises the steps of: warming a mixture of enteric-coated granules containing a physiologically active substance and additive(s) to 25° C. or higher; and compressing the mixture at a predetermined temperature of 25° C. or higher, wherein the physiologically active substance is a physiologically active substance which is unstable to an acid, and wherein the manufacturing process includes a temperature controlling tool for maintaining the temperature of the mixture of enteric-coated granules and additive(s) upon compressing at the predetermined temperature. | ||
| 地址 | Osaka JP | ||