Multidimensional supramolecular structures essentially made of assembled i-motif tetramers

摘要

The present invention pertains to a supramolecular structure based on i-motif tetramers of Cm—X—Cn oligonucleotides, wherein m and n are integers comprised between 2 and 9, and X is a linker such as A, T, G, a modified deoxynucleotide or a diol spacer. These supramolecular structures can be dissociated, when necessary, by a mere pH change. The present invention also relates to methods for obtaining such a supramolecular structure.

主权项

1. A supramolecular structure comprising N Cm—X—Cn (SEQ ID NO: 1) oligonucleotides, wherein m and n are integers between 2 and 7 and m≠n, X is selected from the group consisting of A, T, G, and a modified deoxynucleotide, N is an integer ≧8 and wherein each oligonucleotide is part of an i-motif tetramer.