发明名称 |
Piperidin-4-yl azetidine derivatives as JAK1 inhibitors |
摘要 |
The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase 1 (JAK1) and are useful in the treatment of diseases related to the activity of JAK1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases. |
申请公布号 |
US8765734(B2) |
申请公布日期 |
2014.07.01 |
申请号 |
US201113043986 |
申请日期 |
2011.03.09 |
申请人 |
Incyte Corporation |
发明人 |
Huang Taisheng;Xue Chu-Biao;Li Hui-Yin;Li Qun |
分类号 |
C07D487/04;A61K31/519;C07D471/04;C07D401/14;C07D405/14;A61P35/00;A61P29/00;A61P19/02;C07D519/00 |
主分类号 |
C07D487/04 |
代理机构 |
Fish & Richardson P.C. |
代理人 |
Fish & Richardson P.C. |
主权项 |
1. A compound, which is {1-{1-[3-Fluoro-2-(trifluoromethyl)isonicotinoyl]piperidin-4-yl}-3[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile, or a pharmaceutically acceptable salt thereof. |
地址 |
Wilmington DE US |