Method of diagnosing Sjogren's disease

摘要

Provided are methods and compositions for determining whether an individual has Sjögren's disease (SD). The method entails determining in a biological sample from the individual the presence of antibodies directed to salivary gland protein 1 (SP-I), parotid secretory protein (PSP), carbonic anhydrase 6 (C A6), or determining a combination of the antibodies. Determining that the individual has SD is based on the presence of the antibodies. The method provides for detection of early SD. Kits for antibody detection containing the antigens to which the antibodies of SD patients are directed are also provided.

主权项

1. A method for determining whether an individual has Sjögren's disease (SD) comprising
i) determining in a liquid biological sample from the individual the presence of antibodies directed to salivary gland protein 1 (SP-1), parotid secretory protein (PSP), carbonic anhydrase 6 (CA6), or determining a combination of the antibodies, and determining that the individual has SD based on the presence of the antibodies directed to the SP-1, or to the PSP, or to the CA6, or a combination of said antibodies, in amount that is greater than in a normal control; or determining in the biological sample obtained from the individual the absence of detection of antibodies to PSP and SP-1 and determining based on the absence of detection of the antibodies that the individual does not have SD.