| 摘要 |
PURPOSE: A liquid composition containing 4-[5-(4-methylphenyl)-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide is provided to improve release rate of a celecoxib formulation which is an insoluble drug, to help the absorption of a drug, to enhance bioavailability and AUC (absorption rate), and to shorten drug acting time (Tmax). CONSTITUTION: A liquid composition contains celecoxib as an active ingredient. The liquid composition also contains diethylene glycol monoethyl ether as a solvent and macrogol 15 hydroxy stearate as a surfactant, which are mixed in a weight ratio of 2:8. The liquid composition contains 70-90 wt% of a mixture of the solvent and the surfactant. The liquid composition further contains propylene glycol monocaprylate as a solvent. Diethylene glycol monoethyl ether and propylene glycol monocaprylate are mixed in a weight ratio of 10:0-4:6. [Reference numerals] (AA) Accumulated dissolution rate (%); (BB) Example 7_water; (CC) Example 7_pH1.2; (DD) Example 7_pH4.0; (EE) Example 7_pH6.8; (FF) Selling product_water; (GG) Selling product_pH1.2; (HH) Selling product_pH4.0; (II) Selling product_pH6.8; (JJ) Time (mins) |
