TRANSDERMAL DELIVERY SYSTEM, METHOD FOR TRANSDERMAL ADMINISTRATION AND METHOD OF PREPARING TRANSDERMAL DELIVERY SYSTEM

摘要

The invention relates to a transdermal delivery system comprising a composition comprising a physiologically active agent and a volatile solvent selected from Cto Calkanol in an amount in the range of from 70 to 95% by weight of the total composition and an penetration enhancer, wherein the penetration enhancer comprises a combination of (i) Cto Calkyl ester of salicylic acid in the range of from 0.1 to 10% by weight of the total composition and (ii) polyethylene glycol (PEG) of average molecular weight no more than 300 in an amount at least 0.1% by weight of the total composition, wherein the weight ratio of Cto Calkyl ester of salicylic acid to polyethylene glycol of average molecular weight no more than 300 is in the range of from to 1:10 to 10:1. In another embodiment the present invention relates to the use of such transdermal delivery system for transdermal administration of an active agent to an animal subject. In another embodiment the present invention relates to a method of preparing a transdermal delivery system.