NOVEL ISOFLAVONE GLYCOSIDES AND ANDROGEN RECEPTOR BINDING COMPOSITION OR ANDROGEN RECEPTOR ANTAGONIST COMPOSITION CONTAINING THE ISOFLAVONE GLYCOSIDES

摘要

PROBLEM TO BE SOLVED: To provide an androgen receptor binding composition or androgen receptor antagonist composition containing isoflavone glycoside of American groundnut utilizing the physiological activities after clarifying the chemical structure and physiological activities thereof.SOLUTION: Six species of isoflavone glycoside were isolated from the harvested tuber of Apios americana (American groundnut), then purified and identified. Then these 6 compounds were examined on AR binding activity, ER binding activity and AR agonist action. As a result, they all work as an AR agonist. Based on this finding, provided are an androgen receptor-binding composition or androgen receptor antagonist composition containing the isoflavone glycoside.