| 摘要 |
Discloses composition including mammalian cells committed to the generation of heart tissue, wherein said cells show: i. an observed increase in expression level as compared to a reference of MEF2C and optionally at least one gene further selected from the group consisting of Nkx2.5, Tbx5, GATA4, GATA6, Mesp1, FOG1 FOG2, Flk1; and/or ii. an observed presence of at least one polypeptide species chosen from the group consisting of Nkx2.5, Tbx5, GATA4, GATA6, Mesp1, FOG1 FOG2, Flk1, as compared to a reference and nuclear translocation to the nuclei of the cell of one or more of Nkx2.5 and MEF2C; and at least one pharmaceutically acceptable excipient, wherein the excipient includes at least dimethylsulfoxide (DMSO). |
