| 摘要 |
Provided is a substantially anhydrous pharmaceutical composition of vitamin D derivative for cutaneous application comprising 1-20% by weight of an isotropic solvent mixture of (a) a hydrophilic non-ionic surfactant which is a polyethylene glycol ester of a vegetable oil containing at least 20 mole of ethylene oxide groups/mole of glyceride; (b) a lipophilic non-ionic co-surfactant which is selected from the group consisting of monoglyceride esters of C6-22 fatty acids, diglyceride esters of C6-22 fatty acids, mono- and diglyceride esters of C6-22 fatty acids, propylene glycol esters of C6-22 fatty acids, dialkylene glycol monoalkyl ethers, or polyethylene glycol esters of a triglyceride/vegetable oil containing 4-8 mole of ethylene oxide groups/mole of glyceride; (c) a C6-22 acylglyceride which is a non-amphiphilic C6-22 acylglyceride selected from the group consisting of highly purified vegetable oils such as medium chain triglycerides, long chain triglycerides or castor oil; said isotropic solvent mixture being capable of forming a microemulsion in the presence of an excess of water; the composition further comprising a calcipotriol, calcitriol, tacalcitol, maxacalcitol, paricalcitol and alfacalcidol dissolved or solubilized in said isotropic solvent mixture, and a pharmaceutically acceptable, substantially anhydrous lipid carrier which is a paraffin selected from hydrocarbons with chain lengths from C5 to C60. The composition may be used to treat a dermal disease or condition selected from the group consisting of psoriasis, sebopsoriasis, pustulosis palmoplantaris, dermatitis, ichtyosis, rosacea or acne. |
