| 摘要 |
PURPOSE: A composition for treating central nervous system disease is provided to improve neurobehavioral disorders and cognitive dysfunctions to a level which is similar to the level of a normal animal by restoring neuronal cells in which oligodendrocyte progenitor cells are damaged, thereby being used as cell remedial agents for central nervous system disease. CONSTITUTION: A composition for treating central nervous system disease includes an oligodendrocyte progenitor cell as an active ingredient. The oligodendrocyte progenitor cell is a stem cell which is transformed with an expression vector including an Olig2 gene encoding nucleic acid molecule. The stem cell is a primary cultured stem cell or an immortalized stem cell in which the primary cultured stem cell is genetically transformed. The central nervous system disease is one selected from cerebral palsy (periventicular leukomalacia), multiple sclerosis, spinal cord injury, Lou Gehrig disease or cerebral trauma. |
