| 摘要 |
A combination pharmaceutical composition comprising candesartan cilexetil and amiodipine or a pharmaceutically acceptable salt thereof, a process for the preparation of such composition and unit dosage form comprising such a composition. The composition consists of a granulate containing candesartan cilexetil, polyethylene glycol and other excipients, wherein the weight ratio of candesartan cilexetil to polyethylene glycol is in the range from 5: 1 to 2: 1, and extragranular phase of powder blend comprising amiodipine or a pharmaceutically acceptable salt thereof and excipients. The composition is prepared by mixing the granulate prepared by wet granulation and extragranular phase. |
