| 发明名称 |
MOUSE MODEL OF RETINAL DEGENERATION |
| 摘要 |
The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (AMD). The invention is also directed to non-human animals produced by the methods described herein. Methods of identifying an agent for use in inhibiting one or more pathological characteristics of retinal degeneration and/or AMD is also encompassed by the invention. Also provided is a method of treating AMD in an individual in need thereof comprising, administering to the individual an agent identified herein. |
| 申请公布号 |
US2014182004(A1) |
申请公布日期 |
2014.06.26 |
| 申请号 |
US201414195719 |
申请日期 |
2014.03.03 |
| 申请人 |
THE CLEVELAND CLINIC FOUNDATION ;CASE WESTERN RESERVE UNIVERSITY |
发明人 |
Perez Victor L.;Hollyfield Joe G.;Salomon Robert G. |
| 分类号 |
A61K49/00 |
主分类号 |
A61K49/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration comprising,
a) administering a composition comprising an oxidatively modified protein to a non-human mammal; and b) maintaining the non-human mammal under conditions in which one or more pathological characteristics of retinal degeneration develops in the non-human mammal, thereby producing a non-human mammal having one or more pathological characteristics of retinal degeneration. |
| 地址 |
Cleveland OH US |
