发明名称 |
QUALITY CONTROL METHODS FOR OIL-IN-WATER EMULSIONS CONTAINING SQUALENE |
摘要 |
Measurements of the squalene content in oil-in-water emulsions can be used as a way of checking for problems during production. In particular, it has been found that a drop in squalene content can indicate that filtration problems occurred. Testing the squalene content in the final lots is easier than investigating the characteristics of the filter, and so a squalene assay simplifies the quality control of oil-in-water emulsions. |
申请公布号 |
US2014178428(A1) |
申请公布日期 |
2014.06.26 |
申请号 |
US201314011258 |
申请日期 |
2013.08.27 |
申请人 |
Novartis AG |
发明人 |
Klein Norbert |
分类号 |
A61K39/39;A61K39/145 |
主分类号 |
A61K39/39 |
代理机构 |
|
代理人 |
|
主权项 |
1. A method for manufacturing an oil-in-water emulsion adjuvant, comprising the steps of: (i) preparing a submicron oil-in-water emulsion using known amounts of an aqueous carrier, a surfactant and squalene; (ii) subjecting the emulsion to filter sterilization, to provide a sterilized emulsion; and (iii) measuring the squalene content of the sterilized emulsion. |
地址 |
Basel CH |