Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are diazole lactam derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
申请公布号
WO2014100735(A2)
申请公布日期
2014.06.26
申请号
WO2013US77257
申请日期
2013.12.20
申请人
CHEMOCENTRYX, INC.
发明人
CHEN, XI;DRAGOLI, DEAN R.;FAN, PINGCHEN;JAEN, JUAN C.;LI, YANDONG;POWERS, JAY P.;MALATHONG, VIENGKHAM;PUNNA, SREENIVAS;TANAKA, HIROKO;ZHANG, PENGLIE
