发明名称 TGR5 AGONISTS HAVING AN IMIDAZOLE OR TRIAZOLE CORE WITH SUBTITUENT HAVING A QUATERNARY NITROGEN
摘要 <p>TGR5 (a.k.a. GPBAR1) agonists of structural formula l(Q), (Formula I(Q)) wherein X, R1, R2, and R5 are defined in the specification, pharmaceutically acceptable salts thereof, compositions thereof, and use of the compounds and compositions for treating diseases in which TGR5 is a mediator or is implicated. The invention also comprises use of the compounds in and for the manufacture of medicaments, particularly for treating diseases in which TGR5 is a mediator or is implicated.</p>
申请公布号 WO2014100025(A1) 申请公布日期 2014.06.26
申请号 WO2013US75838 申请日期 2013.12.17
申请人 EXELIXIS, INC. 发明人 FLATT, BRENTON, T.;MOHAN, RAJU
分类号 C07D403/10;A61K31/454;A61P3/04;A61P3/06;A61P3/10 主分类号 C07D403/10
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