发明名称 |
DUAL TARGETING OF MIR-208 AND MIR-499 IN THE TREATMENT OF CARDIAC DISORDERS |
摘要 |
The present invention provides a method of treating or preventing cardiac disorders in a subject in need thereof by inhibiting the expression or function of both miR-499 and miR-208 in the heart cells of the subject. In particular, specific protocols for administering inhibitors of the two miRNAs that achieve efficient, long-term suppression are disclosed. In addition, the invention provides a method for treating or preventing musculoskeletal disorders in a subject in need thereof by increasing the expression or activity of both miR-208 and miR-499 in skeletal muscle cells of the subject. |
申请公布号 |
US2014179764(A1) |
申请公布日期 |
2014.06.26 |
申请号 |
US201314104886 |
申请日期 |
2013.12.12 |
申请人 |
THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
OLSON Eric N.;van Rooij Eva |
分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Austin TX US |