| 发明名称 |
PRIMARY MESENCHYMAL STEM CELLS AS A VACCINE PLATFORM |
| 摘要 |
Episomally transfected primary mesenchymal stem cells (MSC) express a polypeptide consisting of an antigenic polypeptide (e.g., one or more polypeptides) relating to a pathogen (e.g., one or more virus, bacterium, or parasite). The antigenic polypeptide can have the amino acid sequence of a natural polypeptide from the pathogen or an amino acid sequence differing from the natural sequence by one or more conservative amino acid substitutions. Uses and method for treating or preventing infections with episomally transfected primary MSC also are described. |
| 申请公布号 |
US2014178422(A1) |
申请公布日期 |
2014.06.26 |
| 申请号 |
US201314081740 |
申请日期 |
2013.11.15 |
| 申请人 |
The Administrators of the Tulane Educational Fund |
发明人 |
Tomchuck Suzanne L.;Norton Elizabeth B.;Garry Robert F.;Bunnell Bruce;Clements John D. |
| 分类号 |
C12N15/85;A61K39/21 |
主分类号 |
C12N15/85 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Episomally transfected primary mesenchymal stems cells (ETP-MSC) which episomally express at least one polypeptide consisting of an antigenic polypeptide relating to a pathogen; wherein the antigenic polypeptide has the amino acid sequence of a natural polypeptide from the pathogen or has an amino acid sequence differing from the natural sequence by one or more conservative amino acid substitutions. |
| 地址 |
New Orleans LA US |
