| 发明名称 |
Bi-Specific Fusion Proteins |
| 摘要 |
Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network. |
| 申请公布号 |
US2014178380(A1) |
申请公布日期 |
2014.06.26 |
| 申请号 |
US201414187728 |
申请日期 |
2014.02.24 |
| 申请人 |
Merrimack Pharmaceuticals, Inc. |
发明人 |
Nielsen Ulrik;Groton Thomas Wickham;Schoeberl Birgit;Harms Brian;Linggi Bryan;Onsum Matthew;DeLaBarre Byron |
| 分类号 |
A61K47/48;A61K45/06;C07K16/46 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A bi-specific fusion protein comprising:
(a) a targeting domain having a binding specificity to an ischemia-associated molecule; (b) an activator domain that detectably modulates activation of a receptor; and (c) a polypeptide linker, wherein the polypeptide linker extends the half life of the bi-specific fusion protein. |
| 地址 |
Cambridge MA US |
