METHODS OF TREATING HEMOGLOBINOPATHIES

摘要

Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the methods comprise administering an inhibitor selected from an ERK inhibitor, a MEK inhibitor, and a Raf inhibitor. Methods of inhibiting adhesion of sickle red blood cells to endothelial cells are also provided.

主权项

1. A method of alleviating at least one symptom of a hemoglobinopathy in a patient comprising administering an inhibitor selected from a MEK inhibitor, an ERK inhibitor, and a Raf inhibitor.