发明名称 |
METHODS OF GENERATING CELLS WITH MULTILINEAGE POTENTIAL |
摘要 |
The present invention relates to methods for generating mammalian multilineage-potential cells, including mesenchymal stem cells, comprising contacting mammalian somatic cells exhibiting a mature phenotype with PDGF-AB or functional derivative, fragment or mimetic thereof and Azacitidine or functional derivative or analogue thereof for a time and under conditions sufficient to induce the transition of the somatic cells to cells exhibiting multilineage differentiative potential. Also provided are uses of said multilineage-potential cells, such as in promoting tissue repair and regeneration. |
申请公布号 |
WO2014094043(A1) |
申请公布日期 |
2014.06.26 |
申请号 |
WO2013AU01476 |
申请日期 |
2013.12.17 |
申请人 |
NEWSOUTH INNOVATIONS PTY LIMITED |
发明人 |
PIMANDA, JOHN E.;CHANDRAKANTHAN, VASHE |
分类号 |
C12N5/077;A61K31/7068;A61K35/12;A61K38/18;C12N5/0775;C12N5/0789 |
主分类号 |
C12N5/077 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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