发明名称 |
GHRH AGONISTS FOR ISLET CELL TRANSPLANTATION AND FUNCTION AND THE TREATMENT OF DIABETES |
摘要 |
Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient. In some embodiments, the islet cells and/or tissues comprising islet cells may be optionally exposed to GHRH and/or at least one agonist of GHRH prior to transplantation into a patient. In some embodiments, the at least one agonist of GHRH is administered pre-transplantation, concurrently with transplantation, post-transplantation or any combinations thereof. |
申请公布号 |
WO2014100816(A2) |
申请公布日期 |
2014.06.26 |
申请号 |
WO2013US77514 |
申请日期 |
2013.12.23 |
申请人 |
UNIVERSITY OF MIAMI;U.S.A., REPRESENTED BY THE DEPARTMENT OF VETERANSAFFAIRS;DRESDEN UNIVERSITY OF TECHNOLOGY |
发明人 |
SCHALLY, ANDREW, V.;BLOCK, NORMAN, L.;BORNSTEIN, STEFAN;LUDWIG, BARBARA |
分类号 |
A61K35/39;A61K38/25 |
主分类号 |
A61K35/39 |
代理机构 |
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