PROCESS FOR SORAFENIB TOSYLATE POLYMORPH III

摘要

The present invention provides a novel process for the preparation of sorafenib tosylate polymorph III. The preferred embodiment for the preparation of sorafenib tosylate polymorph III, comprises: providing a solution comprising sorafenib, p-toluenesulfonic acid and a solvent selected from a group consisting of a mixture of dimethyl acetamide and an alcoholic solvent, a mixture of dimethylformamide and an alcoholic solvent and a mixture thereof; adding an alcoholic solvent to the solution obtained; isolating the solid; slurring the solid with an alcoholic solvent; and isolating sorafenib tosylate polymorph III.