GEL COMPOSITIONS

摘要

The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight;and propyleneglycolin an amount comprised from 20 to 40% by weight;wherein:the weight ratio between polyvinylpirrolidone: polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratiosforming the combination, the resultingcompositions show a high bioadhesivity and bioavailablity of the active ingredient, without toxic adverse effects.