POLYCATIONIC CALCIUM MODULATOR PEPTIDE FOR THE TREATMENT OF HYPERPARATHYROIDISM AND HYPERCALCEMIC DISORDER

摘要

PROBLEM TO BE SOLVED: To provide polycationic calcium modulator peptides and pharmaceutical compositions thereof, and to provide a method of using such peptides and compositions in methods for decreasing parathyroid hormone (PTH) and/or treating hypercalcemia in a subject in need of such treatment.SOLUTION: A calcium modulator peptide comprises: a) a polycationic peptide comprising 5 to 20 amino acids which are positively charged at physiological pH, an amino terminus, a carboxy terminus, and a first thiol-containing residue, wherein the polycationic peptide is chemically modified at the amino terminus, the carboxy terminus, or both; and b) a cargo peptide comprising a second thiol-containing residue, wherein the second thiol-containing residue is disulfide-bonded to the first thiol-containing residue.