MACROMOLECULE CONJUGATE

摘要

The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules.

主权项

1. A macromolecule comprising;
a. a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three functional groups, b. at least two linear polymers (b) each being bound to one of said functional groups, wherein said polymer (b) at least have one terminal functional groups for cytotoxic agents, and c. one extended polymer (a) being at least 1 atom longer than said polymer (b), being bound to one of said functional groups and having one terminal functional group for a targeting agent.