| 摘要 |
The present invention relates to compounds of Formula (I):;;Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, COPD, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver diseases, and neurodegenerative diseases. |
| 主权项 |
1. A compound of Formula (I): wherein: R1 is C1-C3 alkyl or C3-C6 cycloalkyl, wherein the alkyl or cycloalkyl is optionally substituted with one to three halogen atoms; R2 is hydrogen or C1-C6 alkyl wherein the alkyl is optionally substituted with halo. R3 is hydrogen or C1-C3 alkyl; R4 is hydrogen or C1-C3 alkyl; R5 is hydrogen, C1-C3 alkyl, ORa or —NHRa; R6 is hydrogen, C1-C3 alkyl, C1-C3 haloalkyl, or C3-C6 cycloalkyl wherein the cycloalkyl is optionally substituted with C1-C3 alkyl, C1-C3 haloalkyl, or 1 or 2 halogen atoms; Ra and Rb are independently hydrogen, C1-C3 alkyl or Ra and Rb combine with the nitrogen atom to which they are attached to form a four to six member heterocyclic ring optionally containing an oxygen or a nitrogen atom in the ring; or a pharmaceutically acceptable salt or enantiomer thereof. |
